TB-500 (Thymosin Beta-4 Research Fragment)

Overview

TB-500 refers to synthetic peptide preparations corresponding to Thymosin Beta-4 (Tβ4), a 43-amino-acid protein naturally present in nearly all human and animal cells at high concentration, where it plays a central role in regulating the actin cytoskeleton. Peptide Factory supplies TB-500 as a lyophilized powder for laboratory research applications.

Research Background

Thymosin Beta-4 is the most abundant member of the beta-thymosin family of actin-monomer-binding proteins. Its actin-sequestering activity underlies its role in cell motility, and research over the past two decades has expanded to examine its involvement in wound repair, angiogenesis, and anti-inflammatory signaling in cell and animal models.

Studied Applications

Preclinical and cell-based research on TB-500/Tβ4 has examined:

• Cell migration research — in vitro models have used Tβ4’s actin-binding properties to study keratinocyte, endothelial, and fibroblast migration relevant to wound-closure biology.
• Angiogenesis research — animal models of cardiac and dermal injury have examined Tβ4’s relationship to endothelial cell sprouting and capillary formation.
• Anti-inflammatory signaling research — in vitro studies have investigated Tβ4’s modulation of inflammatory cytokine expression in immune cell cultures.

These findings come from published preclinical and cell-culture literature; TB-500 is not approved for human therapeutic administration and no dosing information is provided.

Storage & Handling

Store lyophilized TB-500 at -20°C, protected from light and moisture. See our storage and handling guidance for reconstitution protocol recommendations.

References

• Goldstein, A. L. & Kleinman, H. K. “Advances in the basic and clinical science of thymosin beta-4.” Ann. N.Y. Acad. Sci. research literature.
• Sosne, G. et al. Thymosin beta-4 and corneal wound healing research models.
• Bock-Marquette, I. et al. Thymosin beta-4 and cardiac progenitor cell migration research.

For Research Use Only — Not for Human Consumption.