Nicotinamide Adenine Dinucleotide (oxidized form)

Overview

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in all living cells, functioning as a central electron carrier in cellular redox reactions and as a required substrate for enzymes including sirtuins and PARPs (poly-ADP-ribose polymerases). Because NAD+ levels are known to decline with age in multiple tissue types, it has become a major focus of preclinical longevity and metabolic research. Peptide Factory supplies research-grade NAD+ as a lyophilized powder.

Research Background

NAD+ exists in an equilibrium with its reduced form, NADH, and this redox couple is fundamental to glycolysis, the citric acid cycle, and oxidative phosphorylation. Beyond its redox role, NAD+ serves as a substrate consumed by sirtuin enzymes (SIRT1-7) and PARP enzymes involved in DNA repair, linking cellular NAD+ availability to research questions in metabolic regulation and genomic stability.

Studied Applications

Preclinical and cell-based research on NAD+ has examined:

• Sirtuin activation research — in vitro and animal studies have investigated the relationship between NAD+ availability and SIRT1/SIRT3 enzymatic activity relevant to mitochondrial biogenesis research.
• DNA repair pathway research — cell models have studied NAD+ as a substrate for PARP-mediated DNA damage response mechanisms.
• Metabolic aging research — rodent models of age-related NAD+ decline have been used to study interventions aimed at restoring cellular NAD+ pools and their downstream effects on mitochondrial and metabolic markers.

These findings reflect laboratory and preclinical research; no dosing or human-use claims are made or implied.

Storage & Handling

NAD+ is more chemically labile than most peptides in this catalog. Store lyophilized powder at -20°C, protected from light and moisture, and avoid repeated freeze-thaw cycles. See our storage and handling guidance for full protocol recommendations.

References

• Imai, S. & Guarente, L. “NAD+ and sirtuins in aging and disease.” Trends Cell Biol. research literature.
• Verdin, E. NAD+ metabolism and cellular signaling research review.
• Canto, C. et al. NAD+ metabolism, mitochondrial function, and aging research.

For Research Use Only — Not for Human Consumption.