Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro)

Overview

Selank is a synthetic heptapeptide developed from the structure of tuftsin, an endogenous immunomodulatory peptide. It was originally characterized by researchers at the Institute of Molecular Genetics (Russian Academy of Sciences) as part of a broader research program into peptide-based anxiolytics and nootropics. Selank is supplied by Peptide Factory as a lyophilized powder for laboratory research applications.

Research Background

Selank’s heptapeptide sequence (Thr-Lys-Pro-Arg-Pro-Gly-Pro) extends the tuftsin tetrapeptide core with a Pro-Gly-Pro tripeptide, a modification associated with improved resistance to enzymatic degradation in early pharmacokinetic research. Preclinical studies have investigated Selank’s interaction with the GABAergic system and its effect on brain-derived neurotrophic factor (BDNF) expression in rodent models, alongside its influence on serotonin and dopamine turnover in specific brain regions.

Studied Applications

In laboratory research settings, Selank has been studied for:

• Anxiolytic-like activity — rodent models of conditioned anxiety and stress-induced behavioral changes have been used to characterize Selank’s effect profile without the sedative or motor-impairing effects associated with benzodiazepine-class compounds.
• Cognitive and memory research — investigations into spatial memory and learning paradigms in animal models, with proposed mechanisms involving BDNF and neurotrophic signaling pathways.
• Immunomodulatory research — as a tuftsin analog, Selank has been examined for effects on cytokine expression profiles in vitro.

These findings are preclinical and reported in the peptide research literature; they describe laboratory observations, not clinical outcomes in humans.

Storage & Handling

Lyophilized Selank should be stored at -20°C, protected from light and moisture, until reconstitution. See our storage and handling guidance for full protocol recommendations.

References

• Kolomin, T. et al. “Neurogenetic and structural-functional characterization of a novel anxiolytic peptide Selank.” Peptides research literature.
• Semenova, T. P. et al. Behavioral pharmacology studies of Selank in rodent anxiety models, Institute of Molecular Genetics RAS.
• Zozulya, A. A. et al. Immunomodulatory effects of tuftsin-derived peptides.

For Research Use Only — Not for Human Consumption.